What does quetiapine do to the brain? It works in the brain, where it affects various neurotransmitters, in particular serotonin (5HT) and dopamine. Quetiapine works by blocking the receptors in the brain that dopamine acts on. This prevents the excessive activity of dopamine and helps to control symptoms of schizophrenia and manic depression. What age group is most affected by schizophrenia? Onset by Age -- Three-quarters of persons with schizophrenia develop the disease between 16 and 25 years of age. -- Onset is uncommon after age 30, and rare after age 40. Onset by Sex -- In the 16-25 year old age group, schizophrenia affects more men than women.
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